Fig. 2: Exploration of substrate scope to synthesize 1,3,4-thiadiazoles from functionalized nitroalkanes and acyl hydrazines. | Nature Communications

Fig. 2: Exploration of substrate scope to synthesize 1,3,4-thiadiazoles from functionalized nitroalkanes and acyl hydrazines.

From: Chemoselective synthesis of 1,3,4-thiadiazoles from acyl hydrazines and nitroalkanes using elemental sulfur

Fig. 2

Reactions were carried out with 0.2 mmol of 1, 0.4 mmol of 2, 0.4 mmol of S8 and 0.36 mmol of Na2S·9H2O in DMF (2 mL) under nitrogen with stirring at rt for 24 h. a Scope of acyl hydrazines; b Scope of nitroalkanes; c Analogue functionalization of bioactive compounds.

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