Fig. 10: Proposed model of CLDN5 regulation of thermogenesis.
From: Adipocyte CLDN5 promotes thermogenesis and energy expenditure through regulation of IL10 expression
CLDN5 is highly enriched in the UCP1 low-expressing adipocytes subpopulation. CLDN5 forms a complex with ZO1 and YBX3 in normal adipocytes under physiological conditions. Mice lacking CLDN5 in adipocytes have reduced heat production, reduced energy consumption, and an obesity-prone phenotype. CLDN5 deletion causes YBX3 to enter the nucleus, promotes the expression and secretion of IL10, and then affects the expression of thermogenic genes in neighboring thermogenic cells through IL10-IL10Ra signaling. The graphic was created in BioRender93.
