Fig. 5: Distribution of major tissues for cardiometabolic traits. | Nature Communications

Fig. 5: Distribution of major tissues for cardiometabolic traits.

From: Uncovering causal gene-tissue pairs and variants through a multivariate TWAS controlling for infinitesimal effects

Fig. 5

A Heatmaps display the major tissues associated with each trait, identified by TGVIS. B Heatmaps display the major tissues associated with each trait, identified by TGFM. The major gene-tissue pairs are cataloged based on stringent criteria (CS-Pratt > 0.15 for TGVIS and PIP > 0.5 for TGFM), and the proportions of major tissues derived from significant gene-tissue pairs for each trait are quantified. Hierarchical clustering is applied to arrange the heatmaps, utilizing the Ward2 method and Euclidean distance. C Major tissues of lipid traits identified by TGVIS and TGFM. This panel shows bar plots detailing the number of causal gene-tissue pairs for various lipid traits, including HDL-C, LDL-C, TC, triglycerides, APOA1, and APOB, as identified by both TGVIS (top) and TGFM (bottom). Source data are provided as a Source Data file. The figure was created in BioRender. Yang, Y. (2025) https://BioRender.com/1s8s2iy.

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