Table 2 Comparison of model performance for the prediction of emotional disorders in girls at age 19

PRS_MDD cutoff	Girls with the higher PRS_MDD (IMAGEN: age 14→age 19)
	N	cases	Model performance (AUC)			GRBMR vs Network	Network vs Baseline
	N	cases	GRBMR	Network	Baseline	GRBMR vs Network	Network vs Baseline
Median	215	105	0.757 ± 0.059	0.747 ± 0.055	0.740 ± 0.058	t = 2.158	t = 2.291
Median	215	105	0.757 ± 0.059	0.747 ± 0.055	0.740 ± 0.058	p = 0.031	p = 0.023
top 45%	192	91	0.779 ± 0.065	0.768 ± 0.071	0.754 ± 0.073	t = 2.240	t = 2.852
top 45%	192	91	0.779 ± 0.065	0.768 ± 0.071	0.754 ± 0.073	p = 0.026	p = 0.005
top 40%	171	81	0.765 ± 0.076	0.753 ± 0.083	0.744 ± 0.085	t = 2.328	t = 2.488
top 40%	171	81	0.765 ± 0.076	0.753 ± 0.083	0.744 ± 0.085	p = 0.021	p = 0.014
top 35%	149	74	0.753 ± 0.067	0.734 ± 0.074	0.725 ± 0.072	t = 2.814	t = 2.228
top 35%	149	74	0.753 ± 0.067	0.734 ± 0.074	0.725 ± 0.072	p = 0.005	p = 0.027
top 30%	128	62	0.767 ± 0.077	0.760 ± 0.078	0.748 ± 0.074	t = 2.410	t = 2.277
top 30%	128	62	0.767 ± 0.077	0.760 ± 0.078	0.748 ± 0.074	p = 0.017	p = 0.024
top 25%	106	50	0.768 ± 0.089	0.759 ± 0.084	0.750 ± 0.093	t = 2.914	t = 2.035
top 25%	106	50	0.768 ± 0.089	0.759 ± 0.084	0.750 ± 0.093	p = 0.004	p = 0.044
top 20%	85	41	0.774 ± 0.103	0.768 ± 0.102	0.760 ± 0.105	t = 2.103	t = 2.529
top 20%	85	41	0.774 ± 0.103	0.768 ± 0.102	0.760 ± 0.105	p = 0.038	p = 0.013
Mean ± sd	70	34	0.750 ± 0.112	0.743 ± 0.121	0.733 ± 0.123	t = 2.158	t = 2.565
Mean ± sd	70	34	0.750 ± 0.112	0.743 ± 0.121	0.733 ± 0.123	p = 0.034	p = 0.012

PRS_MDD, polygenic risk score for major depressive disorder. GRBMR, genetic risk-dependent brain marker of resilience. AUC, area under the curve. The mean and the standard deviation established by repeating a 5-fold cross validation 10 times were reported before and after the ‘±’, respectively. Paired t tests were used to assess the significance of differences in AUC between models, with both t-values and p-values (two-sided) reported.

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