Fig. 7: The multi-functional nano-modulator (siR/RSV @TNP) preferably navigates to the choroid plexus epithelial cells. | Nature Communications

Fig. 7: The multi-functional nano-modulator (siR/RSV @TNP) preferably navigates to the choroid plexus epithelial cells.

From: Targeting modulation of the choroid plexus blood-CSF barrier and CSF hypersecretion via lipid nanoparticle-mediated co-delivery of siRNA and resveratrol

Fig. 7

It can significantly restore blood-cerebrospinal fluid barrier (BCSFB) integrity and inhibit CSF hypersecretion by co-delivery of resveratrol (RSV) and SPAK siRNA. It can effectively attenuate ventriculomegaly and represents a promising therapeutic approach for hydrocephalus. The Scheme was created in BioRender. Gao, H. (2025) https://BioRender.com/i60a962. Agreement number: WL27PVH5O8. Source data are provided as a Source Data file.

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