Fig. 1: Cryo-EM structure of LGR4-Norrin complex.
From: Distinct structural mechanisms of LGR4 modulation by Norrin and RSPOs in Wnt/β-catenin signaling
a, b Cryo-EM structure of the LGR4-Norrin complex with a 2:2 stoichiometry. Cryo-EM map (a) and atomic model (b) are shown. LGR4 and Norrin are colored light green/cyan and violet/orange, respectively. The nanobody segment of MB52 is shown in gray, with other segments omitted for clarity. The color scheme remains consistent throughout the manuscript unless specified otherwise. c, d Views of the extracellular region of the LGR4-Norrin complex: c bottom view of the Cryo-EM map, d bottom view of the atomic model.
