Fig. 5: Integration of RNA-seq and NeuroPainting data links cell adhesion gene expression to mitochondrial morphology. | Nature Communications

Fig. 5: Integration of RNA-seq and NeuroPainting data links cell adhesion gene expression to mitochondrial morphology.

From: Combining phenomics with transcriptomics reveals cell-type-specific morphological and molecular signatures of the 22q11.2 deletion

Fig. 5

a Scatter plot of first CCA variables (CV1) for RNA-seq and NeuroPainting profiles, colored by condition (control = green, 22q11.2 = purple). b Heatmap of correlation coefficients between gene expression and morphology feature values for the top 100 genes and the top 100 features from CCA loadings. Correlation difference is measured as the absolute value between the control and deletion coefficients. c Scatter plot of absolute differences in correlation coefficients against fold change coefficients between control and 22q11.2 deletion astrocytes for gene-feature pairs. d Barplot for morphology feature categories for cell adhesion gene-feature pairs (chi-square test, Two-sided, χ² = 28.655, df = 6, p-value = 7.069e-05). e The Dotplot highlights the absolute difference in correlation coefficients between control and 22q11.2 astrocytes for cell adhesion gene-mitochondrial feature pairs.

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