Fig. 9: Assessment of potent antitumor effect of FeS@SRB-based therapy on subcutaneous B16F10 tumor-bearing mice. | Nature Communications

Fig. 9: Assessment of potent antitumor effect of FeS@SRB-based therapy on subcutaneous B16F10 tumor-bearing mice.

From: Living therapeutics of nonpathogenic bacteria as biosynthesis factory and active carriers for enhancing tumor-targeted therapy

Fig. 9

A Schematic illustration of the treatment process. B Representative infrared thermal images of mice in different groups under irradiation with 808 nm laser (1.5 W cm−2, 5 min) on tumors after 48 h post-i.v. injection with PBS, SRB, FeS@BSA, and FeS@SRB, respectively. C Corresponding temperature change curves of tumor tissues. n = 3 biological independent replicates. Data are presented as mean ± SD. D Tumor growth curves in different groups. n = 5 biological independent replicates. Data are presented as mean ± SD. E Photos of tumor tissues harvested on the 14th day. F Mice weight change curves during the treatment period. n = 5 biological independent replicates. Data are presented as mean ± SD. G Representative H&E staining, TUNEL and Ki67 immunofluorescence staining images of tumor tissues in different groups on the 14th day after various treatments. Scale bar: 200 μm. H Representative H&E staining images of liver tissues in various groups on the 14th day after various treatments (yellow line: vacuolated cytoplasm; green line: inflammatory foci; blue line: portal vein stasis). Scale bar: 200 μm. G1, Control; G2, SRB; G3, FeS@BSA; G4, FeS@BSA + NIR; G5, FeS@SRB; G6, FeS@SRB + NIR. Source data are provided as a Source Data file. The experimental design diagram was created in BioRender. Dong, M. (2025) https://BioRender.com/sjw0c3j.

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