Fig. 3: Brain systems for affective arousal. | Nature Communications

Fig. 3: Brain systems for affective arousal.

From: A neurofunctional signature of affective arousal generalizes across valence domains and distinguishes subjective experience from autonomic reactivity

Fig. 3

a Shows the thresholded BAAS weight maps based on 5000 samples bootstrap test (q < 0.05, FDR corrected). b Displays brain regions that significantly (two-sided P < 0.001, uncorrected, equivalent to FDR q < 0.002) predict affective arousal experience in both discovery (10 × 10-fold cross validation) and validation cohorts revealed by parcellation-based analysis. Statistical significance was assessed using Pearson correlations between predicted and actual outcomes. c Summarizes multivariate patterns trained on individual subjects and depicts brain regions that consistently predict subjective affective arousal across n = 60 participants (the discovery cohort) using a one-sample t-test (q < 0.05, FDR corrected) based on training a separate model for each subject’s trial by trial ratings. In (a) and (c), hot color indicates positive values, whereas cold color indicates negative values. In (b), hot color indicates the averaged prediction-outcome Pearson correlation coefficients from the discovery cohort and validation cohort. BAAS Brain affective arousal signature, aIns anterior insula, Amyg amygdala, dmPFC dorsomedial prefrontal cortex, FG fusiform gyrus, IFG inferior frontal gyrus, lOFC lateral orbitofrontal cortex, MFG middle frontal gyrus, MOG middle occipital gyrus, PAG periaqueductal gray, PCC posterior cingulate cortex, PHG parahippocampal gyrus, pIns posterior insula, sACC subgenual anterior cingulate, SFG superior frontal gyrus, SMA supplementary motor area. Source data are provided as a Source Data file.

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