Fig. 1: Outline of this work.

a Representative biologically active multi-substituted cyclobutanes. b Substrate-dependent divergent ring-opening of BCB-Bpin. c Palladium catalyzed α-selective alkenylation of BCBs. d Synthesis of cyclobutanes by ring-opening of BCBs. e Catalyst-dependent regiodivergent hydrophosphination of acyl BCBs.