Fig. 5: Enantioselective synthesis of tetrahydroisoquinolines. | Nature Communications

Fig. 5: Enantioselective synthesis of tetrahydroisoquinolines.

From: Enantioselective synthesis of chiral 2,3-cis-disubstituted piperidines and C1-substituted tetrahydroisoquinolines by asymmetric Cu-catalyzed cyclizative aminoboration

Fig. 5

aReaction conditions: 1) 9 (0.25 mmol), B2pin2 (1.5 eq.), Cu(CH3CN)4PF6 (10 mol%), (S,S)-Ph-BPE (10 mol%), LiOtBu (3 eq.), THF (2 mL), 24 h; 2) NaBO3·4H2O (5 eq.), THF/H2O (v/v = 2/1). Isolated yields; ee values were determined by chiral HPLC. busing Bpin-Bdan as B source.

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