Fig. 9: In vivo therapeutic effects of P-Mn/TI@mHSA in ApoE−/− mice. | Nature Communications

Fig. 9: In vivo therapeutic effects of P-Mn/TI@mHSA in ApoE−/− mice.

From: A programmable platelet theranostic platform for adaptive multi-stage delivery and synergistic immunotherapy in atherosclerosis

Fig. 9

a Experimental outline illustrating the treatment procedure for evaluating the therapeutic efficacy of various formulations in atherosclerotic mice. Created in BioRender. Li, W. (2025) BioRender.com/7bg16oh. b Representative photographs of en face ORO-stained aortas from each mouse after various treatments. c Quantitative analysis of plaque lesion areas in the tested aortas. d Representative images and e quantitative analysis of ORO-stained plaque lesion in aortic root sections. Scale bar = 50 μm. f Representative images of HE-stained aortic root sections and g quantitative analysis of lesion areas based on H&E staining. Scale bar for H&E images was 50 μm, and scale bar for H&E-zoom images was 20 μm. h Fluorescence images of DHE-stained aortic root sections and i corresponding relative fluorescence intensity of DHE after different treatments. Scale bar for DHE images was 50 μm, and scale bar for DHE-zoom images was 20 μm. j The levels of pro-inflammatory TNF-α and k IL-6 in serum, detected using ELISA assay. For (c, e, g, i, j, k), data are presented as mean ± SD (n = 5 mice). Statistical significance was determined using one-way ANOVA. Source data are provided as a Source Data file.

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