Fig. 1: Pediatric FGFR1-altered tumors are enriched in glioneuronal histologies. | Nature Communications

Fig. 1: Pediatric FGFR1-altered tumors are enriched in glioneuronal histologies.

From: A diverse landscape of FGFR alterations and co-mutations suggests potential therapeutic strategies in pediatric low-grade gliomas

Fig. 1

a Heatmap showing hierarchical clustering of the methylation data (top 10,000 differentially methylated probes; ward D2; Euclidean distance) for the 425 patients in the KiTZ cohort. This heatmap shows beta-values as indicated by the color scale. Cluster 1 and 2, 2A and 2B are labeled on the heatmap. Metadata highlighted include if the tumor was FGFR-altered, which FGFR gene was altered or co-altered, which alteration type, the methylation family prediction, tumor grade, and if it was a glioneuronal tumor. b Co-mutation plot summarizing alterations in the FGFR genes and other recurrently mutated genes across 120 FGFR-altered pediatric tumors in the three cohorts (DFCI, KiTZ, FM). The co-mutation plot is ordered by FGFR alteration type, patient age, and grade. N/A- data not available. FM- Foundation Medicine. c Horizontal bar plots depicting the top 5 significant Gene Ontology C5 (MsigDB) terms enriched (ranked by significance) in FGFR1- (n = 16) or BRAF-altered (n = 130) gliomas. Negative log(FDR) values from the GSEA analysis are shown on the x-axis. Source data are provided in Supplementary Data S2 and S3 and the Source Data File.

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