Fig. 2: Expression of FGFR1 is found in neuronal and glial lineage cell types in brain development. | Nature Communications

Fig. 2: Expression of FGFR1 is found in neuronal and glial lineage cell types in brain development.

From: A diverse landscape of FGFR alterations and co-mutations suggests potential therapeutic strategies in pediatric low-grade gliomas

Fig. 2

a Expression of FGFR1 in bulk RNA-seq across lifespan in human forebrain (n = 55) (left) and hindbrain (n = 59) (right). X-axis denotes sample age, measured in natural log of weeks post conception, and x-axis tick values correspond to weeks in prenatal points and years in postnatal points. Vertical dashed line depicts birth. Y-axis depicts RPKM expression values. b, c UMAP representation of human embryo cells 4–5.5 weeks post conception. N = 7 embryos, 185k cells. b Left: Cells colored by neural progenitor cells annotated in the original study colored green. c Right: Cells colored by normalized expression of FGFR1. Color scale midpoint is set to the midpoint of maximum and minimum expression. d Detection rate (% of cells with expression >0) of FGFR1 expression in broad cell types of first trimester human brain. e Top 15 cell clusters by detection rate (% of cells with expression of >0) of Fgfr1 expression in developing mouse pons and forebrain. Cell clusters grouped by broad cell type.

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