Table 1 Performance of PCM score in the diagnosis of pancreatic cancer
From: Cell-free DNA testing for the detection and prognosis prediction of pancreatic cancer
| Â | Testing Cohort | External Validation Cohort 1 | External Validation Cohort 2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Â | AUC | Sensitivity (%) | Specificity (%) | Accuracy (%) | AUC | Sensitivity (%) | Specificity (%) | Accuracy (%) | AUC | Sensitivity (%) | Specificity (%) | Accuracy (%) |
Cancer vs Non-cancer | ||||||||||||
All stages | 0.9794 (0.9614–0.9976) | 97.78 (86.77–99.88) | 90.54 (85.71–93.91) | 91.76 (87.62–94.56) | 0.9921 (0.9828–1) | 91.84 (79.52–97.35) | 96.67 (89.88–99.14) | 94.96 (89.51–97.78) | 0.9862 (0.9712–1) | 90 (75.40–96.75) | 97.75 (91.35–99.61) | 95.35 (89.72–98.10) |
Stage I/II | 0.9815 (0.9630–1) | 96.77 (81.49–99.83) | 90.54 (85.71–93.91) | 91.3 (86.96–94.35) | 0.9944 (0.9866~1) | 89.29 (70.63~97.19) | 96.67 (89.88~99.14) | 94.92 (88.80~97.92) | 0.9933 (0.9845~1) | 88.89 (69.70~97.09) | 97.75 (91.35~99.61) | 95.69 (89.74~98.40) |
Stage I | 0.987 (0.966–1) | 100 (59.77–100) | 90.54 (85.71–93.91) | 90.87 (86.19–94.13) | 0.9954 (0.9871~1) | 83.33 (50.88~97.06) | 96.67 (89.88~99.14) | 95.1 (88.39~98.18) | 0.9947 (0.9864~1) | 94.74 (71.89~99.72) | 97.75 (91.35~99.61) | 97.22 (91.50~99.28) |
Stage II | 0.9796 (0.9563–1) | 95.65 (76.03–99.77) | 90.54 (85.71–93.91) | 91.02 (86.54–94.16) | 0.9938 (0.9842~1) | 93.75 (67.71~99.67) | 96.67 (89.88~99.14) | 96.23 (90.06~98.78) | 0.9803 (0.9543~1) | 75 (35.58~95.55) | 97.75 (91.35~99.61) | 95.88 (89.18~98.67) |
Stage III/IV | 0.9844 (0.9674–1) | 100 (67.96–100) | 90.54 (85.71–93.91) | 90.99 (86.37–94.20) | 0.9882 (0.9733~1) | 93.75 (67.71~99.67) | 96.67 (89.88~99.14) | 96.23 (90.06~98.78) | 0.9809 (0.9447~1) | 92.31 (62.09~99.60) | 97.75 (91.35~99.61) | 97.06 (91.02~99.24) |
Pancreatic cancer vs Healthy | ||||||||||||
All stages | 0.9928 (0.9835~1) | 97.78 (86.77~99.88) | 96.45 (92.08~98.55) | 96.73 (93.10~98.56) | 0.9978 (0.9944~1) | 91.84 (79.52~97.35) | 98.82 (92.71~99.94) | 96.27 (91.07~98.62) | 0.9893 (0.9763~1) | 90 (75.40~96.75) | 98.81 (92.63~99.94) | 95.97 (90.37~98.51) |
Stage I/II | 0.9945 (0.9855~1) | 96.77 (81.49~99.83) | 96.45 (92.08~98.55) | 96.5 (92.63~95.46)) | 0.9992 (0.9972~1) | 89.29 (70.63~97.19) | 98.82 (92.71~99.94) | 96.46 (90.65~98.86) | 0.9960 (0.9892~1) | 88.89 (69.70~97.09) | 98.81 (92.63~99.94) | 96.4 (90.49~98.84) |
Stage I | 0.9970 (0.9906~1) | 100 (59.77~100) | 96.45 (92.08~98.55) | 96.61 (92.43~98.61) | 0.9990 (0.9963~1) | 83.33 (50.88~97.06) | 98.82 (92.71~99.94) | 96.91 (90.58~99.20) | 0.9969 (0.9910~1) | 94.74 (71.89~99.72) | 98.81 (92.63~99.94) | 98.06 (92.48~99.66) |
Stage II | 0.9936 (0.9817~1) | 95.65 (76.03~99.77) | 96.45 (92.08~98.55) | 96.35 (92.33~98.39) | 0.9993 (0.9972~1) | 93.75 (67.71~99.67) | 98.82 (92.71~99.94) | 98.02 (92.34~99.66) | 0.9940 (0.9829~1) | 75 (35.58~95.55) | 98.81 (92.63~99.94) | 96.74 (90.09~99.15) |
Stage III/IV | 0.9975 (0.9929~1) | 100 (67.86~100) | 96.45 (92.08~98.55) | 96.67 (92.55~98.64) | 0.9949 (0.9865~1) | 93.75 (67.71~99.67) | 98.82 (92.71~99.94) | 98.02 (92.34~99.66) | 0.9831 (0.9501~1) | 92.31 (62.09~99.60) | 98.81 (92.63~99.94) | 96.74 (90.09~99.15) |
