Table 2 Performance of PCM score in the diagnosis of pancreatic cancer compared with CA19-9 (Pancreatic cancer vs PBT + CP)
From: Cell-free DNA testing for the detection and prognosis prediction of pancreatic cancer
PCM Score | Testing cohort | External Validation cohort 1 | External Validation cohort 2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
AUC | Sensitivity (%) | Specificity (%) | Accuracy (%) | AUC | Sensitivity (%) | Specificity (%) | Accuracy (%) | AUC | Sensitivity (%) | Specificity (%) | Accuracy (%) | |
All stages | 0.9371 (0.8872~0.9870) | 97.78 (86.77~99.88) | 71.7 (57.44~82.80) | 83.67 (74.54~90.10) | 0.8939 (0.7611~1) | 91.84 (79.52~97.35) | 60 (17.04~92.74) | 88.89 (76.69~95.40) | 0.935 (0.8575~1) | 90 (75.40~96.75) | 80 (29.88~98.95) | 88.89 (75.15~95.84) |
Stage I/II | 0.9404 (0.8873~0.9934) | 96.77 (81.49~99.83) | 71.7 (57.44~82.80) | 80.95 (70.62~88.40) | 0.9142 (0.7939~1) | 89.29 (70.63~97.19) | 60 (17.04~92.74) | 84.85 (67.33~94.28) | 0.9481 (0.8729~1) | 88.89 (69.70~97.09 | 80 (29.88~98.95) | 87.5 (70.07~95.92) |
Stage I | 0.9552 (0.8876~1) | 100 (59.77~100) | 71.7 (57.44~82.80) | 75.41 (62.44~85.15) | 0.8124 (0.7143~1) | 83.33 (50.88~97.06) | 60 (17.04~92.74) | 76.47 (49.76~92.18) | 0.9579 (0.8830~1) | 94.74 (71.89~99.72) | 80 (29.88~98.95) | 91.67 (71.53~98.54) |
Stage II | 0.9352 (0.8712~0.9992) | 95.65 (76.03~99.77) | 71.7 (57.44~82.80) | 78.95 (67.78~87.13) | 0.9 (0.7506~1) | 93.75 (67.71~99.67) | 60 (17.04~92.74) | 85.71 (62.64~96.24) | 0.925 (0.7662~1) | 75 (35.58~95.55) | 80 (29.88~98.95) | 76.92 (45.98~93.84) |
Stage III/IV | 0.9262 (0.8052~1) | 100 (67.86~100) | 71.7 (57.44~82.80) | 76.56 (64.02~85.88) | 0.875 (0.7067~1) | 93.75 (67.71~99.67) | 60 (17.04~92.74) | 85.71 (62.64~96.24) | 0.9077 (0.7647~1) | 92.31 (62.09~99.60) | 80 (29.88~98.95) | 88.89 (63.93~98.05) |
CA 19-9 | Testing cohort | External Validation cohort 1 | External Validation cohort 2 | |||||||||
All stages | 0.8091 (0.7163~0.9018) | 72.73 (56.96~84.54) | 82.00 (68.08~90.95) | 77.66 (67.67~85.34) | 0.7617 (0.4345~1) | 87.23 (79.52~97.35) | 80 (29.88~98.95) | 86.54 (73.59~93.97) | 0.7208 (0.4375~1) | 72.50 (55.86~84.86) | 66.67 (12.53~98.23) | 74.42 (58.53~85.96) |
Stage I/II | 0.8373 (0.7344~0.9403) | 80.00 (60.87~91.59) | 82.00 (68.08~90.95) | 81.25 (70.65~88.79) | 0.8037 (0.4189~1) | 96.30 (79.11~99.81) | 80 (29.88~98.95) | 93.75 (77.78~98.91) | 0.7469 (0.4831~1) | 81.48 (69.70~97.09) | 66.67 (12.53~98.23) | 80.00 (60.87~91.60) |
Stage I | 0.8525 (0.7068~0.9982) | 75.00 (35.58~95.55) | 82.00 (68.08~90.95) | 81.03 (68.19~89.71) | 0.8 (0.408~1) | 100 (69.87~100) | 80 (29.88~98.95) | 94.12 (69.24~99.69) | 0.7895 (0.5363~1) | 89.47 (65.46~98.16) | 66.67 (12.53~98.23) | 86.36 (64.04~96.41) |
Stage II | 0.8318 (0.7077~0.9559) | 81.82 (58.99~94.01) | 82.00 (68.08~90.95) | 81.94 (70.74~89.67) | 0.8067 (0.4275~1) | 93.33 (66.03~99.65) | 80 (29.88~98.95) | 90.00 (66.87~98.25) | 0.6458 (0.256~1) | 62.5 (25.89~89.76) | 66.67 (12.53~98.23) | 76.92 (45.98~93.84) |
Stage III/IV | 0.7782 (0.5896~0.9668) | 63.64 (31.61~87.63) | 78.69 (65.98~87.74) | 78.69 (65.98~87.74) | 0.675 (0.3999~0.95) | 68.75 (41.48~87.87) | 80 (29.88~98.95) | 71.43 (47.69~87.81) | 0.6667 (0.2906~1) | 53.85 (26.12~79.60) | 66.67 (12.53~98.23) | 56.25 (30.55~79.25) |
