Fig. 6: Proposed reaction mechanism and the DFT calculated free-energy profile from difluorocarbene to the product. | Nature Communications

Fig. 6: Proposed reaction mechanism and the DFT calculated free-energy profile from difluorocarbene to the product.

From: Multi-component reactions via copper(I) difluorocarbene as carbonyl source for constructing α—aminoamide derivatives

Fig. 6

Copper-difluorocarbene was demonstrated as the key intermediate rather than free difluorocarbene for formation of ylide intermediate IV, and subsequently ylide interception, defluorination and carbonyl migration process were energetic feasibility.

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