Fig. 4: Bidirectional stereospecific positional alkene isomerization to axially chiral N-indolylquinolinones. | Nature Communications

Fig. 4: Bidirectional stereospecific positional alkene isomerization to axially chiral N-indolylquinolinones.

From: Stereospecific positional alkene isomerization enables bidirectional central-to-axial chirality transfer

Fig. 4

Reaction conditions: DBN (0.1 mmol, 0.1 mmol/mL) was rapidly added to 1a (0.1 mmol) in 1,4-dioxane (5 mL), or DABCO (0.025 mmol, 0.1 mmol/mL) was rapidly added to 1a (0.1 mmol) in MeOH (5 mL) at rt for 5–10 min. Isolated yield, the ee values were determined by chiral HPLC.

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