Fig. 6: Combining positional and geometrical alkene isomerization for the stereodivergent synthesis of diaxially chiral compounds 5 with all eight stereoisomers. | Nature Communications

Fig. 6: Combining positional and geometrical alkene isomerization for the stereodivergent synthesis of diaxially chiral compounds 5 with all eight stereoisomers.

From: Stereospecific positional alkene isomerization enables bidirectional central-to-axial chirality transfer

Fig. 6

A Reaction conditions for stepwise AASI, (P)-2c or (M)-2c (0.1 mmol), phenyl MBH carbonates (0.2 mmol), (DHQD)2PYR or (DHQ)2PYR (20 mol%), DME (1.0 mL), rt; then MeONa, toluene (1.0 mL), rt. B Reaction conditions for photocatalytic Z/E isomerization, (Z)-5 (0.1 mmol), Ir(ppy)3 (1 mol%), 420 nm LED, THF (1.0 mL), rt.

Back to article page