Fig. 5: The counterfactual generation results produced by CausCell.
From: Causal disentanglement for single-cell representations and controllable counterfactual generation
a Gene expression differences among different ages in the original dataset, where C4b in Oligo (n = 6717 cells), Xdh in Endo (n = 5220 cells) and Gpc5 in Astro (n = 6675 cells). b Gene expression differences among different ages in the counterfactually generated dataset, where C4b in Oligo (n = 6717 cells), Xdh in Endo (n = 5220 cells) and Gpc5 in Astro (n = 6675 cells). c GO enrichment analysis of the differentially expressed upregulated genes in microglia enriched in the striatum domain, performed using the hypergeometric test. d Age-related Lilrb4a gene expression differences across all cell types, including Astro (n = 6675 cells), Endo (n = 5220 cells), ExN (n = 17307 cells), InN (n = 4149 cells), MSN (n = 17205 cells), Micro (n = 1725 cells), Olig (n = 6717 cells) and Peri (n = 333 cells). e Lilrb4a expression differences among different ages in the original dataset. f Spatial segmentation results concerning the anatomical regions of the mouse brain. g The spatial distribution characteristics of Lilrb4a expression across all ages. In the GO enrichment analysis, a hypergeometric test was performed. In each boxplot, the box boundaries represent the interquartile range, the whiskers extend to the most extreme data points within 1.5 times the interquartile range, the value indicated above the box represents the mean value, and the black line inside the box represents the median. In subfigures (a, b), statistical tests were conducted via a two-sided t test with significance levels of ns: p > 0.05; *: p ≤ 0.05; **: p ≤ 0.01; ***: p ≤ 0.001; ****: p ≤ 0.0001). In subfigure (d), an analysis of variance (ANOVA) test was used. The exact p-values are provided in Source data. Source data are provided as a Source Data file.
