Fig. 3: Calcium-dependent interaction between CD163 and Hb-Hp1.
From: Calcium-dependent oligomerization of scavenger receptor CD163 facilitates the endocytosis of ligands
a Cryo-EM map of Hb-Hp1 binding to SRCR2-4 of two CD163 protomers after local refinement. b Structural model of CD163 protomers bound to Hb-Hp1. c Interactions between CD163 and Hb-Hp1 complex. d NHS-pull down analyses of Hb-Hp binding activity of recombinant CD163 variants, with each experiment has been repeated at least twice. Overexpressed and purified CD163 variants were incubated with ligand-bound beads in the presence of 2.5 mM calcium. Source data are provided as a Source Data file.
