Fig. 7: Proposed role of GPR139 in homeostatic scaling of inhibitory effects of dynorphin. | Nature Communications

Fig. 7: Proposed role of GPR139 in homeostatic scaling of inhibitory effects of dynorphin.

From: Homeostatic scaling of dynorphin signaling by a non-canonical opioid receptor

Fig. 7

At a low level of dynorphin release, only canonical opioid receptors (MOR/KOR/DOR) are engaged to inhibit neuronal activity via Gi/o signaling. More dynorphin release upon increase in the activity of dynorphinergic neurons progressively engages GPR139, which gradually counteracts MOR/KOR/DOR thereby avoiding excessive silencing of neuronal activity to maintain operating range of the circuit. Created in BioRender. Martemyanov, K. (2025) https://BioRender.com/mlzlbxs.

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