Fig. 3: Single nuclei transcript profiling of E14.5 miR-200 inhibited cardiac tissue. | Nature Communications

Fig. 3: Single nuclei transcript profiling of E14.5 miR-200 inhibited cardiac tissue.

From: Single-nuclei multiomics analysis identifies abnormal cardiomyocytes in a murine model of cardiac development

Fig. 3

A UMAP representation of single nuclei transcriptomes from wild-type, PMIS-A, PMIS-C, and PMIS-AC clustered for cell types. Unsupervised clustering identified 9 unique cell clusters. B Fraction of annotated cell clusters from each sample. C UMAP representation of single nuclei transcriptomes from wild-type, PMIS-A, PMIS-C, and PMIS-AC. D Heatmap showing the average expression for the top differentially expressed genes between E14.5 cardiac cell clusters. E Differentially expressed genes for WT v PMIS in cardiac cell clusters. The p-values were obtained using the two-sided Wilcoxon rank-sum test, adjusted for multiple comparisons using the Benjamini-Hochberg procedure. F UMAP representation of single nuclei transcriptomes subclustered for cell type. Unsupervised clustering identified 18 unique cell clusters, including 5 unique CM clusters.

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