Fig. 3: Tumor responses. | Nature Communications

Fig. 3: Tumor responses.

From: Tumor control and immune activation through palliative irradiation and ATR inhibition, PATRIOT Part C: a phase Ib trial

Fig. 3

A–E example responses with corresponding radiotherapy plans. Legend indicates the isodose levels, expressing the percentage of prescribed radiation dose (either 20 or 30 Gy). Red arrowheads indicate the tumor. A metastatic squamous cell carcinoma of the larynx, mediastinal node treated with 20 Gy and 20 mg BD ceralasertib, best response was PR. B metastatic SCCHN, acetabulum metastasis treated with 20 Gy and 40 mg ceralasertib, best response was PR. C SCCHN (hypopharynx) treated with 20 Gy and 40 mg ceralasertib, best response was PR and later clinical CR. D SCCHN (oropharynx) treated with 30 Gy and 80 mg ceralasertib, best response was PR. E SCCHN treated with 30 Gy and 80 mg ceralasertib, best response was PR. F spider plot of change in diameter, compared to baseline measurement, for irradiated lesions only. G waterfall plot, of change in diameter, compared to baseline measurement, for irradiated lesions only. H Swimmer plot, indicating clinical course for each participant.

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