Fig. 5: Hyperactive olfactory system in socially isolated (SS) groups. | Nature Communications

Fig. 5: Hyperactive olfactory system in socially isolated (SS) groups.

From: Differential impacts of social isolation and enriched environment on multi-sensory brain-wide functionality and network segregation

Fig. 5

a fMRI experimental design. b Group-averaged BOLD response maps in SS, SG, and EG in response to olfactory stimulation (two-tailed one-sample t-test, p < 0.01, cluster-corrected with defining threshold Z > 2.3). Scale bar = 2 mm. c BOLD response from piriform cortex in SS (n = 6; blue), SG (n = 8; red), and EG (n = 8; green). The orange bar represents the stimulation duration. d Area under the curve (AUC) values from bilateral olfactory limbic and polymodal areas. Significant areas after two-way ANOVA with Tukey’s correction are bold and italics in e. Data are presented as the mean ± SEM (Kruskal-Wallis test corrected with Dunn’s test, *p < 0.05, **p < 0.01) (MOB main olfactory bulb, AON anterior olfactory nucleus, TTd dorsal tenia tecta, PIR piriform cortex, BNST bed nucleus of the stria terminalis, NAc nucleus accumbens, PVH paraventricular hypothalamus, AHN anterior hypothalamus, LPO lateral preoptic area, VTA ventral tegmental area, PAG periaqueductal gray, RSC retrosplenial cortex, PPC posterior parietal cortex, LP lateral posterior thalamus, PO posterior thalamus, LD lateral dorsal thalamus, Hb habenula, MD, mediodorsal thalamus, S1BF whisker primary somatosensory cortex, V2am higher order anteromedial visual area). Exact p-values are provided in the source data. Source data are provided as a Source Data file.

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