Fig. 6: Functional hyperconnectivity socially isolated (SS) groups. | Nature Communications

Fig. 6: Functional hyperconnectivity socially isolated (SS) groups.

From: Differential impacts of social isolation and enriched environment on multi-sensory brain-wide functionality and network segregation

Fig. 6

a Group-averaged independent component analysis (ICA) maps of all three groups (SS, SG, and EG) are presented as individual networks, along with the location of the prominent seeds of each network (defining threshold Z > 2.3). b A functional connectivity (FC) matrix (56 × 56) with regions of interest (ROIs) based on the observed networks for SS (n = 6; blue), SG (n = 8; red), and EG (n = 8; green). The bottom triangle is unthresholded, and the top triangle is symmetrically thresholded at |r| > 0.2. c Graph theory and network segregation metrics of the whole brain. d Mean within-diagonal functional connectivity (FC) within the PLN and TH networks. e Network segregation between two specific networks. Higher values indicate segregated networks. Data are presented as the mean ± SEM (Kruskal-Wallis test, corrected with Dunn’s test; *p < 0.05, **p < 0.01). (ACC anterior cingulate, RSC retrosplenial, ORF orofacial, Wh/FL whisker/forelimb, HL/tr hindlimb/trunk, PLN posterior lateral network, HPC hippocampal network, TH thalamic, OLF olfactory, STR striatum). Source data are provided as a Source Data file.

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