Fig. 2: Trophoblast-specific knockout of Piezo1 causes embryonic lethality in mice.
From: PIEZO1 drives trophoblast fusion and placental development
A Breeding scheme for the generation of Piezo1 conditional knockout (cKO) mice. B Genotype distribution of wild-type (WT), heterozygous (HET), and cKO pups compared to the expected Mendelian inheritance ratio. The numbers of animals with specific genotypes over 105 pups were shown in the parentheses. C Representative embryos and placentas from Piezo1 WT, HET, and cKO mice at embryonic day 13.0 (E13.0). Images of the complete litter can be found in Fig. S5B.
