Fig. 4: Molecular crosstalk between native insulin and DBS products.
From: Spatially constrained disulfide bond shuffling delays insulin aggregation and enhances neurotoxicity
a Representative native IM-MS spectrum showing the noncovalent interactions between monomeric insulin and DBS products. Insulin – native, untreated group as a control (0.5 mg/mL); A/B – insulin treated with TCEP (0.5 mg/mL); (Insulin + A/B) – the incubation group between native insulin and TCEP reduction products. b Representative CID spectrum for characteristic crosstalk products (AB-A/AB-B/AB-BB). c Native IM-MS heatmap showing the disruption of native insulin oligomerization with DBS products. Source data for (a, b) are provided as a Source Data file.
