Fig. 1: Conceptual design of the BEAM system. | Nature Communications

Fig. 1: Conceptual design of the BEAM system.

From: A continuously oxygenated macroencapsulation system enables high-density packing and delivery of insulin-secreting cells

Fig. 1

The system comprises two integral components: an implantable electrochemical oxygen generator (iEOG) and a core-shell cell encapsulation pouch designed in linear configuration to facilitate minimally invasive implantation, connected by gas-impermeable tubing. A Schematic representation illustrating oxygen generation by electrolytic splitting of tissue moisture. A human sketch is shown to indicate the relative size of a human version system (The power supply needed for electrolysis is not shown). B A representative digital image of a scaled-up BEAM system with a cell encapsulation pouch measuring 15 cm in length and 5 mm in thickness. C Longitudinal section view of the cell encapsulation pouch showing pancreatic islets located in the annular space between an inner silicone tubing and the semipermeable membrane for optimal mass transportation and proximity between cells and the oxygen source. Figure (A) was partly created in BioRender. Pham, T. (2025) https://BioRender.com/k5wqwwr.

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