Fig. 2: In situ oxygen generation of iEOGs. | Nature Communications

Fig. 2: In situ oxygen generation of iEOGs.

From: A continuously oxygenated macroencapsulation system enables high-density packing and delivery of insulin-secreting cells

Fig. 2

A A digital image comparing the dimensions of v1 iEOG and v2 iEOG. B Representative 18-h measurements of oxygen flow rate, current, and voltage from a v1 iEOG operated at 10 mA over 2.5 years, collected on day 121, 186, and 879. C Oxygen generation rates of v1 iEOGs operated at 11 mA, measured before and 3 months post-implantation in RNU nude rats (n = 4). Data are presented as mean ± SD. Statistical analysis was performed using paired two-tailed Student’s t-test. D Oxygen generation rates of v2 iEOGs operated at 11 mA, measured 2 months post-implantation in RNU nude rats (n = 8). Data are presented as mean ± SD. E Oxygen generation rates of v2 iEOGs operated at 11 mA, measured before and 1 month after implantation in immunocompetent SD rats (n = 3). Data are presented as mean ± SD. Statistical analysis was performed using paired two-tailed Student’s t test. F A representative stereomicroscope image showing a v2 iEOG implanted in the subcutaneous space of SD rats after 1 month. The skin was removed to exposure the implant. G Masson’s trichrome staining of tissue surrounding the iEOG after 1 month of implantation in SD rats. Arrowheads indicate the presence of blood vessels.

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