Fig. 3: Phenome-wide analyses of the association between USP and future disease risk.
From: Health risks and genetic architecture of objectively measured multidimensional sleep health
Manhattan plot-style visualization assessing the relationship between sleep profiles and future disease risk. A Cox proportional hazards model was applied to each phenotype using the two-sided Wald test, adjusted for age, sex, ethnicity, diet, smoking status, alcohol consumption, education, self-rated health, body mass index, season, moderate-to-vigorous physical activity, and Townsend deprivation index. Uncorrected P-values are plotted, with a blue dashed line indicating the Bonferroni-corrected significance threshold for α ≤ 0.05 and a red dashed line representing the Benjamini-Hochberg false discovery rate (FDR) cutoff at 0.05. USP: unhealthy sleep profile. Source data are provided as a Source Data file.
