Fig. 4: Forest plot of significant incident disease phenotypes in the phenome-wide analyses.
From: Health risks and genetic architecture of objectively measured multidimensional sleep health
A Cox proportional hazards model was applied to each phenotype using the two-sided Wald test, adjusted for age, sex, ethnicity, diet, smoking status, alcohol consumption, education, self-rated health, body mass index, season, moderate-to-vigorous physical activity, and Townsend deprivation index. The significant threshold is defined by multiple comparisons using the Bonferroni correction (\(0.05/526=9.51\times {10}^{-5}\)). Uncorrected P-values are plotted. Left: Effect sizes from the Cox models are presented as hazard ratios (HRs) with 95% confidence intervals (CIs), using the favorable sleep profile as the reference. Right: Significance of the effect size. Source data are provided as a Source Data file.
