Fig. 5: Manhattan plots and Q-Q plots for variants associated with USP.
From: Health risks and genetic architecture of objectively measured multidimensional sleep health
a Manhattan plots for WES single variant analysis. The horizontal line indicates the genome-wide significant level of \(5\times {10}^{-9}\). b Quantile-quantile plots for WES single variant analysis. c Manhattan plots for WES gene-centric coding analysis. The horizontal line indicates a genome-wide STAAR-O P-value threshold of \(2.5\times {10}^{-6}\). The significant threshold is defined by multiple comparisons using the Bonferroni correction (\(0.05/{{\mathrm{20,000}}}=2.50\times {10}^{-6}\)). d Quantile-quantile plots for WES gene-centric coding analysis. e Manhattan plots for WGS single variant analysis. The horizontal line indicates the genome-wide significant level of \(5\times {10}^{-9}\). f Quantile-quantile plots for WGS single variant analysis. g Manhattan plots for WGS gene-centric noncoding analysis. The horizontal line indicates a genome-wide STAAR-O P-value threshold of \(2.5\times {10}^{-6}\). The significant threshold is defined by multiple comparisons using the Bonferroni correction (\(0.05/{{\mathrm{20,000}}}=2.50\times {10}^{-6}\)). h Quantile-quantile plots for WGS gene-centric noncoding analysis. i Manhattan plots for WGS ncRNA analysis. The horizontal line indicates a genome-wide STAAR-O P-value threshold of \(2.5\times {10}^{-6}\). The significant threshold is defined by multiple comparisons using the Bonferroni correction (\(0.05/{{\mathrm{20,000}}}=2.50\times {10}^{-6}\)). j Quantile-quantile plots for WGS ncRNA analysis. In panels, (a−i) the chromosome number are indicated by the colors of dots. In all panels, STAAR-O is a two-sided test. USP: unfavorable sleep profile; WES: whole exome sequencing; WGS: whole genome sequencing; STAAR-O: omnibus test in the STAAR framework.
