Fig. 1: Design and mechanisms of CAR for multiplex imaging and urinalysis of IRI in the liver-kidney axis. | Nature Communications

Fig. 1: Design and mechanisms of CAR for multiplex imaging and urinalysis of IRI in the liver-kidney axis.

From: Unimolecular near-infrared chemiluminescent reporter for cascaded multiplex imaging of ischemia-reperfusion injury in the liver-kidney axis

Fig. 1

a The effects of liver ischemia duration on the induction of AKI. The severity of HIRI-induced AKI is highly associated with the duration of liver ischemia. b Schematic illustration of CAR for imaging of O2•− and NAG and urinalysis. After systemic administration of CAR into living mice, it efficiently accumulates into the liver and specifically liberates NIR-II CL signal to report O2•− levels, followed by inducing self-elimination to defragment the backbone of CAR and effectively releasing the NIR-I CL reporter (KIR) to the kidneys for sensing NAG levels, finally excreting out for fluorescently urinalysis. c Chemical structures of CAR and its fragments in response to O2•− and NAG, respectively. Source data are provided as a Source Data file.

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