Fig. 3: Identification and characterizations of the four Inocle taxa. | Nature Communications

Fig. 3: Identification and characterizations of the four Inocle taxa.

From: Giant extrachromosomal element “Inocle” potentially expands the adaptive capacity of the human oral microbiome

Fig. 3

A Workflow for identification of additional Inocle contigs. Discovery analysis using long-read contigs acquired from 46 Japanese participants identified 13 Inocle contigs and InoC genes. The representative predicted 3D structure of InoC is shown; the green region indicates the replication-relaxation domain in the InoC. To expand the number of Inocle contigs, circular contigs encoding an InoC were identified using high-quality long-read contigs obtained from 46 Japanese, 9 Indonesian, and 1 Thailand participants. B Phylogenetic tree of the 29 InoC amino acid sequences. The red, blue, purple, and yellow colors indicate Inocle-α, β, γ, and δ, respectively. C Comparative protein repertoires of 29 Inocles. The horizontal axis indicates protein families (PFs) of Inocles, and the vertical axis represents each Inocle. The heatmap shows the presence (gray) or absence (white) of each PF in each Inocle. The taxon of each Inocle corresponds with the color code used in (B). D Prevalence of Inocles across the seven countries. The size of each circle shows the prevalence of each Inocle taxon in each country. E The average abundance of each Inocle taxon in each body site.

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