Fig. 5: Functional characterization of Inocles. | Nature Communications

Fig. 5: Functional characterization of Inocles.

From: Giant extrachromosomal element “Inocle” potentially expands the adaptive capacity of the human oral microbiome

Fig. 5

A The ratio of subcellular localization in 1619 Inocle protein families. B–D Functionally annotated genes of Inocles in cytoplasmic genes (B), unknown subcellular localization genes (C), and cell wall/membrane-related genes (D). The gray and white heatmap indicates the existence of each gene in each Inocle taxon. The functional categories of the KEGG BRITE are shown for each gene. Genes with confirmed transcriptional activity in saliva are shown in a red heatmap. E–H Representative 2D structure of the bifunctional transglycosylase (E), sortase A (F), LPXTG-like motif protein (G), and signal peptidase (H) on the membrane. I Gene functions of the homologous genes between Inocles and Streptococcus chromosomes. The bar plot indicates the number of homologous genes between Inocles and Streptococcus chromosomes in each function.

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