Fig. 9: Alterations in OLFM2 signaling are connected to obesity.

Framework proposal laid out during this research, which consequentially connects obesity to changes in OLFM2 levels during adipogenesis and upon the inflammatory activation of adipocytes. In turn, impaired OLFM2 may compromise adipocyte phenotype in obesity through the disruption of paramount mechanisms in adipocyte function, as differentiation, cell cycle and focal adhesion, to the point of exacerbate the pathogenesis of adipocyte hypertrophy and impaired metabolism in mice. Coincidentally, scrutiny of OLFM2 gene variants (GWAS) and the metabolic phenotype of our Olfm2-null mouse model further suggests physiological implications connecting OLFM2 to obesity-related traits. Created in BioRender. Gómez Serrano, M. (2025) https://BioRender.com/0l2biim.