Table 1 Lead GWAS SNP
Trait | SNP | CHR | BP (hg19) | Effect Allele | Non-effect Allele | Effect Allele freq | Beta | SE | P | Nearest gene | *HetDf | *HetI2 | *HetP |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Broad-sense strabismus | rs1996371 | 15 | 78956806 | T | C | 0.62 | −0.030 | 0.0053 | 9.58 × 10−9 | CHRNA4 | 9 | 29.7 | 0.172 |
Broad-sense strabismus | rs6420484 | 17 | 79612397 | A | G | 0.38 | 0.056 | 0.0062 | 1.72 × 10−19 | NPLOC4 | 8 | 47.5 | 0.05453 |
Broad-sense strabismus | rs8108303 | 19 | 53100998 | A | G | 0.81 | −0.038 | 0.0065 | 8.31 × 10−9 | ZNF701 | 9 | 0 | 0.8807 |
Broad-sense strabismus | rs2150458 | 21 | 47377296 | A | G | 0.45 | 0.029 | 0.0051 | 2.46 × 10−8 | COL6A1 | 10 | 37.2 | 0.102 |
Esotropia | rs228636 | 1 | 7917557 | T | C | 0.59 | −0.063 | 0.011 | 1.67 × 10−8 | UTS2 | 2 | 0 | 0.6154 |
Esotropia | rs1996371 | 15 | 78956806 | T | C | 0.62 | −0.055 | 0.0099 | 2.97 × 10−8 | CHRNA4 | 6 | 44.2 | 0.0962 |
Esotropia | rs4468638 | 16 | 80531515 | A | G | 0.26 | 0.068 | 0.012 | 1.58 × 10−8 | DYNLRB2 | 5 | 0 | 0.7485 |
Esotropia | rs8070929 | 17 | 79530993 | T | C | 0.38 | 0.071 | 0.012 | 1.14 × 10−9 | FAAP100 | 5 | 20.8 | 0.2766 |
Exotropia | rs4908704 | 1 | 7918904 | A | G | 0.76 | −0.089 | 0.013 | 1.27 × 10−11 | UTS2 | 2 | 0 | 0.4103 |
Exotropia | rs3778977 | 7 | 2159746 | T | C | 0.38 | −0.088 | 0.013 | 4.34 × 10−11 | MAD1L1 | 1 | 59.4 | 0.1166 |
