Table 2 Rare variant-based gene-centric analysis identified lung cancer-associated genes, which were replicated in the matched annotation category in the replication stage
Gene name | Chr | Start | End | Discovery category | Discovery P-valuea | Replication category | Replication P-valuea |
|---|---|---|---|---|---|---|---|
ENO1 | 1 | 8861000 | 8879190 | Promoter | 1.52 × 10−04 | Promoter | 2.92 × 10−03 |
EFHD2 | 1 | 15409888 | 15430339 | Enhancer | 7.08 × 10−05 | Enhancer | 2.18 × 10−02 |
MACF1 | 1 | 39081316 | 39487177 | Missense | 9.03 × 10−05 | Missense | 4.74 × 10−02 |
LRRFIP2 | 3 | 37052626 | 37183689 | Promoter | 7.72 × 10−05 | Promoter | 1.64 × 10−02 |
PSMB9 | 6 | 32844136 | 32859851 | Enhancer | 1.58 × 10−04 | Enhancer | 3.15 × 10−02 |
C11orf21 | 11 | 2295645 | 2303049 | Enhancer | 1.94 × 10−05 | Enhancer | 2.80 × 10−02 |
RAD52 | 12 | 911736 | 990053 | Missense | 4.22 × 10−05 | Missense | 1.96 × 10−02 |
RITA1 | 12 | 113185526 | 113192368 | Enhancer | 1.13 × 10−04 | Enhancer | 4.56 × 10−02 |
PLA2G4C | 19 | 48047843 | 48110817 | Promoter | 5.67 × 10−05 | Promoter | 7.66 × 10−04 |
