Fig. 1: Asymmetric [3 + 2] annulation of propargylic esters to chiral dihydrofuran derivatives with cyclic quaternary stereocenters. | Nature Communications

Fig. 1: Asymmetric [3 + 2] annulation of propargylic esters to chiral dihydrofuran derivatives with cyclic quaternary stereocenters.

From: Enantioselective construction of cyclic quaternary stereocenters via dinuclear copper catalyzed asymmetric [3 + 2] propargylation/annulation

Fig. 1

a Selected examples of important molecules with cyclic chiral quaternary carbon center. b Cu-catalyzed propargylation/cycloisomerization reactions. c Proposed binuclear Cu-allenylidene intermediates. d This work: dinuclear copper-catalyzed [3 + 2] annulation of tertiary propargylic esters with a diverse set of C,O bis-nucleophiles.

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