Fig. 9: Cartoon showing the mechanism by which the SERBP1-PCIF1 complex in S1HLGlu neurons contributes to the development and maintenance of neuropathic pain and comorbid anxiety. | Nature Communications

Fig. 9: Cartoon showing the mechanism by which the SERBP1-PCIF1 complex in S1HLGlu neurons contributes to the development and maintenance of neuropathic pain and comorbid anxiety.

From: SERBP1-PCIF1 complex-controlled m6Am modification in glutamatergic neurons of the primary somatosensory cortex is required for neuropathic pain in mice

Fig. 9

Peripheral nerve injury induces an increase in the SERBP1-PCIF1 complex, which in turn regulates m6Am-controlled MAF1 expression in S1HL, leading to reduced inhibition and enhanced neuronal excitability (drawn by figdraw.com).

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