Fig. 7: Fed-batch culture of the engineered CHO cells. | Nature Communications

Fig. 7: Fed-batch culture of the engineered CHO cells.

From: Boosting energy metabolism and biosynthesis in diverse organisms by a common bacterial salvage lipoylation protein

Fig. 7

a VCD during the fed-batch culture. b Canakinumab titer measured from day 5 to day 10. c qIgG from day 6 to day 10. d Glucose consumption and addition in the medium. e Lactate production and consumption in the medium. f The ratio of qLac/qGluc before glucose addition. g Pyruvate, h glutamate, i Glutamine concentration in the medium. Specific consumption rate of glucose (j), lactate (k), and glutamate (l) during the fed-batch culture. Data were represented as mean ± SD (n = 3, n biologically independent samples). Multiple unpaired two-sided t-test was used for the statistical analyses for (b, c, j–l). P adjustments were made for multiple comparisons. Source data are provided as a Source Data file.

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