Fig. 1: Synthesis of gem-difluorides. | Nature Communications

Fig. 1: Synthesis of gem-difluorides.

From: Modular synthesis of CF2-containing compounds with PhSO2CF2H reagent through difluoromethylene radical anion synthon strategy

Fig. 1

a Synthetic route to gem-difluorides and its bioisostere. b Previously developed difluoromethylene synthon. c Challenges for difluoromethylene radical anion synthon (diFRAS). d This work: PhSO2CF2H as diFRAS for modular synthesis of gem-difluorides with chemical complexity. FG functional group, LG leaving group, PG protecting group.

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