Fig. 1: Cryo-EM structures of the APJR-βarr1 and APJRF101A-βarr1 complexes bound with cmpd644. | Nature Communications

Fig. 1: Cryo-EM structures of the APJR-βarr1 and APJRF101A-βarr1 complexes bound with cmpd644.

From: Mechanistic insights into the versatile stoichiometry and biased signaling of the apelin receptor-arrestin complex

Fig. 1

a–c Cryo-EM maps and structure models of all three APJR-βarr1 complexes reported in this study, shown in two orientations and colored by chain: APJR-βarr1 complex at a 2:2 stoichiometry (yellow, APJR; pink, βarr1; gray, scFv30; light purple, cmpd644) (a); APJR-βarr1 at a 2:1 stoichiometry (yellow, APJR coupled with βarr1; green, APJR uncoupled with βarr1; pink, βarr1; gray, scFv30; light purple, cmpd644) (b); APJRF101A-βarr1 complex (blue, APJRF101A-βarr1; pink, βarr1; gray, scFv30; orange, cmpd644) (c).

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