Fig. 7: External source of serine/glycine is crucial to keep anabolic balance in NSCLC with respiration defect.
From: Respiration defects limit serine synthesis required for lung cancer growth and survival
Graphical abstract illustrating the mechanisms discussed in this study. From top to bottom: NSCLC cells with functional mitochondria and no limitation of external substrates; the same cells under serine/glycine starvation; and NSCLC cells with impaired mitochondrial function combined with serine/glycine starvation. The size of the metabolite labels represents the relative increase or decrease of the indicated substrate. Green triangles denote increased levels of the substrate or phenotype, while red triangles indicate decreased levels. Red Xs represent the absence of the specified metabolite. This Figure was created in Biorender. Cararo Lopes, E and White, E (2025).
