Fig. 5: Integrating ear scRNA-seq to build a hair cell differentiation GRN.
From: prdm1a drives a fate switch between hair cells of different mechanosensory organs
a–e UMAPs of integrated scRNA-seq, showing sibling lateral line, prdm1a-/- lateral line, embryo otic subset, ear scRNA-seq, and complete integration, respectively. f Integrated ear prdm1a-/- hair cell cluster with cells color coded by cell type from the ear scRNA-seq annotation5. prdm1a-/- hair cells are in gray. g Heatmap of mature hair cell genes of the triple integrated scRNA-seq data set, divided into prdm1a-/- lateral line cells, ear hair cells of the embryo otic subset and ear scRNA-seq data sets. h GRN of zebrafish lateral line hair cell specification and development. i GRN of zebrafish ear hair cell specification and development. j GRN of mouse inner hair cell specification and development. k GRN of mouse outer hair cell specification and development. Numbers in brackets indicate citations for the individual interactions.
