Fig. 8: Graphic summary of this research.
From: Targeting spermine metabolism to overcome immunotherapy resistance in pancreatic cancer
Spermine levels are markedly elevated in the plasma of pancreatic cancer patients and correlate with poor prognosis. In tumor cells, Serpinb9 directly interacts with spermine synthase to hinder its lysosomal degradation, thereby augmenting the biosynthesis of spermine. Inhibiting Serpinb9 or its interaction with spermine synthase enhances the efficacy of pancreatic cancer immunotherapy. This Figure was created with BioRender. Hanshen, Y. (https://BioRender.com/dwim8mz).
