Fig. 10: Panx1 expression correlates with senescence and fibrosis in patients with acute kidney disease. | Nature Communications

Fig. 10: Panx1 expression correlates with senescence and fibrosis in patients with acute kidney disease.

From: Noncanonical function of Pannexin1 promotes cellular senescence and renal fibrosis post-acute kidney injury

Fig. 10

Analysis of renal biopsies from control (Ctrl, n = 8 patients) and AKD (n = 9 patients) cohorts. a Serum creatinine (Cr) levels. b Representative PAS staining and quantification of tubular injury. Scale bars, 20 µm. c Representative immunohistochemistry and quantification of Panx1-positive area. Scale bars, 20 µm. d Representative SA-β-Gal staining and quantification. Scale bars, 100 µm. e Representative Sirius Red staining and quantification of fibrosis. Scale bars, 50 µm. For b–e images are representative of all patients analyzed in each group. Correlation analyses (n = 17 total patients) between renal Panx1 expression and f eGFR, g SA-β-Gal activity, and h Sirius Red staining. i Schematic illustrating the proposed mechanism of Panx1-mediated senescence. This schematic was created with Figdraw. Data are presented as means ± SD. P values for a–e were determined by a two-sided Student’s t-test. P values for f–h were determined by Pearson’s correlation analysis. Exact P values are provided in the Source Data file. ***P < 0.001.

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