Fig. 3: Trans-hierarchical asymmetric signaling measured by the transport plan. | Nature Communications

Fig. 3: Trans-hierarchical asymmetric signaling measured by the transport plan.

From: Connectome-constrained ligand-receptor interaction analysis for understanding brain network communication

Fig. 3

A The low-to-high hierarchical signaling propagation of the ligand-receptor interactions was more preferred than the high-to-low rank defined by the functional connectivity (FC) gradient (KS = 0.1055, P = 3.66 × 10−27) and the sensorimotor-association (SA) axis (KS = 0.1121, P = 1.41 × 10−30) rather than anatomical gradient (KS = 0.0059, P = 8.29 × 10−1). Two-sample one-tailed Kolmogorov-Smirnov test was performed. B The trans-hierarchical asymmetric signaling was larger than expected under the spatial-preserving embedding model (10000 surrogates) for the functional connectivity gradient (P = 0.0327) and SA axis (P = 0.0329) but not the anatomical gradient (P = 0.761). Spin test was performed to adjust potential spatial autocorrelations (10000 surrogates). The red solid line is the observed values. Source data are provided in a Source data file.

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