Table 1 Issues and recommendations
From: Current challenges and future directions for brain age prediction in children and adolescents
1. BAG interpretation | Use longitudinal data to capture BAG stability and dynamics |
2. Model training | Ensure diverse, representative samples with sufficient power |
3. Study design | Prioritize longitudinal designs |
4. Model performance and specificity | Report multiple fit metrics for comparability and weight/features used |
5. Nonlinearity | Address nonmonotonic and nonlinear trends |
6. Corrections and other biases | Address site/scanner effects and adjust for biases |
